Fu Laboratory

Research in the Fu lab focuses on disorders related to inflammation and thrombotic diseases, conditions that can be enhanced by our own immune systems. White blood cells respond to local sites of infection by releasing a host of factors capable of destroying invading pathogens and bacteria. One of the immune responses is to generate bacteria-killing oxidants which work just like bleach to "disinfect." However, these powerful oxidants can also damage the surrounding healthy tissue, causing organ and/or blood vessel injury.

Our research uses mass spectrometry and biochemical methods to better understand the pathophysiology (abnormal functional changes) of a wide range of diseases related to inflammation and thrombosis and develop methods for prevention and new therapeutic strategies.

Areas of Study

  • The oxidation, cleavage, and mutations of blood clotting proteins
  • Storage lesion of blood components using metabolomics based approaches
  • Clinical trials to evaluate antioxidant therapy and identify biomarkers for oxidative stress

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Notable discoveries

  • NAC treatment corresponds with a decrease in protein bound cysteine in SCD and TTP patients undergoing clinical trials.
  • Poly-unsaturated fatty acids and their oxidation products accumulate in both leukoreduced and non-leukoreduced red blood cell and platelet units.
  • Developed an assay that incorporates mass-spectrometry and immunoprecipitation to quantitatively measure mutations, oxidation, and cleavage of VWF in the plasma of patients with clotting and bleeding disorders.

Dr Fu's Background

  • Joined Bloodworks Northwest as an associate member in 2008.
  • Ph.D. in Chemistry from Zhejiang University (China)
  • Served as Professor of Chemistry at Zhejiang University
  • Joined the faculty at the University of Washington School of Medicine in 2002
 

Xiaoyun Fu, PhD
Associate Member
Director of Mass Spectrometry Laboratory

Research Associate
Professor of Medicine
Division of Hematology
University of Washington School of Medicine

Bloodworks Northwest
Research Institute
1551 Eastlake Avenue E, Suite 100
Seattle, WA 98102

Email: xiaoyunf@bloodworksnw.org
UW Mailstop 359190
Phone: (206) 568-2200
FAX: (206) 587-6056

Rachel A. Sessum
Sr. Administrative Coordinator
Email: rachels@bloodworksnw.org
Phone: (206) 568-2246
FAX: (206) 587-6056